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Overview: Tramadol 225 mg is a heavy-duty, maximum-strength formulation designed specifically for long-term chronic pain management. It is almost exclusively manufactured as an Extended-Release (ER/SR) tablet to ensure the high dose is delivered safely and evenly throughout the day.
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Target Patient Profile: This strength is not intended for minor or short-term pain. It is prescribed only to opioid-tolerant patients whose severe pain cannot be managed by standard doses.
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Critical Safety Warning (Do Not Crush): These tablets must be swallowed whole. Never crush, chew, split, or dissolve a 225 mg tablet. Doing so disrupts the extended-release mechanism, causing the entire high dose to enter the bloodstream at once (dose-dumping), which can result in a fatal overdose.
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